2018 CGA Annual Meeting
President: Heather Hampel, MS, LGC
The Ohio State University
Wexner Medical Center
1:05 – 1:30 PM Anne Krush Lectureship
Introductions by Jessica Stoll, MS, CGC
PDF Introduction Slides: Anne Krush Lecture Introduction
Juvenile Polyposis Syndrome
Joy Larsen Haidle, MS, LGC
PDF JPS Slides: Juvenile Polyposis Syndrome
Recorded Presentation: Juvenile Polyposis Syndrome
1:30 – 2:35 PM General Session I: Hamartomatous
Moderator: Bryson W. Katona, MD, PhD; Brandie Heald Leach, MS, LGC
Peutz-Jeghers Syndrome Surveillance
Thomas McGarrity, MD
PDF Slides: Peutz-Jeghers Syndrome Surveillance
Recorded Presentation: Peutz-Jeghers Syndrome Surveillance
Cowden Syndrome (mTOR Inhibitors)
Peter P. Stanich, MD
PDF Slides: mTOR Inhibitors
Recorded Presentation: Cowden Syndrome (mTOR Inhibitors)
Recorded Discussion: Panel Discussion
Joy Larsen Haidle, MS, LGC; Thomas McGarrity, MD; Peter P. Stanich, MD
3:00 PM – 4:30 PM Presidential Plenary Abstract Session I
Moderators: Heather Hampel, MS, LGC; Sonia S. Kupfer, MD
A multi-institutional analysis of therapy-associated polyposis in survivors of childhood and young adulthood cancers
Leah Biller, MD
PDF Slides: A multi-institutional analysis of therapy-associated polyposis in survivors of childhood
Recorded Presentation: A multi-institutional analysis of therapy-associated polyposis in survivors of childhood
Cancer risks for relatives of people with serrated polyposis
Aung Win, MBBS, MPH, PhD
PDF Slides: Cancer risks for relatives of people with serrated polyposis
Recorded Presentation: Cancer risks for relatives of people with serrated polyposis
EGD and Colonoscopy Findings in a Prospective Series of Patients with PTEN-Hamartoma Tumor Syndrome
Brandie Heald Leach, MS, LGC
PDF Slides: EGD and Colonoscopy Findings in a Prospective Series of Patients with PTEN-Hamartoma Tumor
Recorded Presentation: EGD and Colonoscopy Findings in a Prospective Series of Patients with PTEN-Hamartoma Tumor Syndrome
Clinical and molecular characterization of MSH3 monoallelic germline mutation carriers
Erin E. Salo-Mullen, MS, MPH, CGC
PDF Slides: Clinical and molecular characterization of MSH3 monoallelic germline mutation carriers
Recorded Presentation: Clinical and molecular characterization of MSH3 monoallelic germline mutation carriers
Endoscopic Imaging Criteria to Identify High Risk Polyps Associated with Gastric Adenocarcinoma in Familial Adenomatous Polyposis
Gautam Mankaney, MD
Recorded Presentation: Endoscopic Imaging Criteria to Identify High Risk Polyps Associated with Gastric Adenocarcinoma in Familial Adenomatous Polyposis
ATZ Neoplasia: A Comprehensive examination of a dangerous phenomenon
Matthew F. Kalady, MD
Recorded Presentation: ATZ Neoplasia: A Comprehensive examination of a dangerous phenomenon
Genomic and transcriptomic profiling of duodenal adenomas in familial adenomatous (FAP) and MUTYH-associated polyposis (MAP)
Elena Meuser, MSc
Recorded Presentation: Genomic and transcriptomic profiling of duodenal adenomas in FAP and MAP
An international study of duodenal disease in MAP: incidence of polyposis and cancer
Laura Thomas, BSc, PhD
Recorded Presentation: An international study of duodenal disease in MAP
Social Determinants of Health are Associated with Lower Rates of Genetic Testing in Individuals at Risk for Lynch Syndrome in the National Health Interview Survey
Joshua Prenner
Recorded Presentation: Social Determinants of Health are Associated with Lower Rates of Genetic Testing in Individuals at Risk for Lynch Syndrome in the National Health Interview Survey
Underdiagnosis of Hereditary Colorectal Cancer in Medicare patients: genetic testing criteria miss the mark
Ed Esplin, MD, PhD, FACMG, FACP
Recorded Presentation: Underdiagnosis of Hereditary Colorectal Cancer in Medicare patients: genetic testing criteria miss the mark
4:30 – 5:15 PM Challenging Cases
Moderated by Matthew F. Kalady, MD
Recorded Presentation: Challenging Cases
5:15 – 5:25 PM Late-Breaking Abstract
CDH1 Penetrance Estimates Are Lower Than Once Thought
Brian H. Shirts, MD, PhD
Recorded Presentation: CDH1 Penetrance Estimates Are Lower Than Once Thought
Day 2: October 15, 2018
8:00 – 8:30 AM Jeremy Jass Lectureship
Introductions by Jessica N. Everett, MS, CGC
PDF Slides: Jass Lecture Introduction
Prevalence of Mutations in Pancreatic Cancer
Gloria M. Petersen, PhD
PDF Slides: Prevalence of Mutations in Pancreatic Cancer
Recorded Presentation: Prevalence of Mutations in Pancreatic Cancer
8:30 – 10:00 AM General Session II: Hereditary Pancreatic Cancer
Moderators: Beth Dudley, MS, MPH, CGC; Aimee Lucas, MD, MS
PARP Inhibitors and Tumors with HRD
James M. Ford, MD
PDF Slides: Targeting PARP DNA Repair in Pancreatic Cancer
Recorded Presentation: PARP Inhibitors and Tumors with HRD
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Pancreatic Cancer Surveillance
Randall E. Brand, MD
PDF Slides: Pancreatic Cancer Surveillance
Recorded Presentation: Pancreatic Cancer Surveillance
Biomarkers in Pancreatic Cancer Surveillance
Diane M. Simeone, MD
PDF Slides: Biomarkers in Pancreatic Cancer Surveillance
Recorded Presentation: Biomarkers in Pancreatic Cancer Surveillance
Recorded Discussion: Panel Discussion
Randall E. Brand, MD; James M. Ford, MD; Gloria M. Petersen, PhD; Diane M. Simeone, MD
10:30 AM – 12:20 PM General Session III: What Can The Tumor Tell Us?
Moderators: Maria Baker, PhD, FACMG, MS, LGC; Sigurdis Haraldsdottir, MD, PhD
MSI by NGS/Exome/Promega and Tumor Sequencing
Zsofia K. Stadler, MD
PDF Slides: NA
Recorded Presentation: MSI by NGS/Exome/Promega and Tumor Sequencing
Ultra-Hypermutated Tumors – Foundation Medicine
Brittany B. Campbell, PhD
PDF Slides: Ultra-Hypermutated Tumors – Foundation Medicine
Recorded Presentation: Ultra-Hypermutated Tumors
APC Somatic Mosaicism
Luigi Ricciardiello, MD
PDF Slides: Somatic APC mosaicism
Recorded Presentation: APC Somatic Mosaicism
Immunotherapy
Michael J. Overman, MD
PDF Slides: Immunotherapy for Solid Cancers- The Role of Deficient Mismatch Repair (dMMR)
Recorded Presentation: Immunotherapy
Record Discussion: Panel Discussion
Brittany B. Campbell, PhD; Michael J. Overman, MD; Luigi Ricciardiello, MD; Zsofia K. Stadler, MD
2:00 – 2:30 PM Lemuel Herrera Lectureship
Introductions by Sonia S. Kupfer, MD
PDF Slides: Jass Lecture Introduction
Familial Colorectal Cancer Guideline from CAG and AGA
David A. Lieberman, MD
PDF Slides: Clinical Practice Guideline on Screening for Colorectal Cancer in Individuals with a family history
Recorded Presentation: Familial Colorectal Cancer Guideline from CAG and AGA
2:30 – 4:00 PM General Session IV: Risk Assessment
Moderators: Dennis J. Ahnen, MD; Melyssa Aronson, MS, (C)CGC
PREMM5
Fay Kastrinos, MD, MPH
PDF Slides: The PREMM5 Model
Recorded Slides: The PREMM5
NCCN Guidelines: Challenging Issues
Samir Gupta, MD, MSCS, AGAF
PDF Slides: National Comprehensive Cancer Network Guidelines - Challenging Issues
Recorded Slides: Challenging Issues
Risk Assessment in the Community
Daniel Luba, MD
PDF Slides: Risk Assessment in the Community
Recorded Slides: Risk Assessment in the Community
Recorded Discussion: Panel Discussion
Samir Gupta, MD, MSCS, AGAF; Fay Kastrinos, MD, MPH; David A. Lieberman, MD; Daniel Luba, MD
6:00 – 7:00 PM Lifetime Achievement Award Presentation
Introductions by Swati G. Patel, MD
PDF Slides: Lifetime Achievement Introductions
Sometimes It Takes a Village of Villages
Dennis J. Ahnen, MD
PDF Slides: Sometimes It Takes a Village of Villages
Recorded Presentation: Sometimes It Takes a Village of Villages
Day 3: Tuesday, October 16, 2018
8:00 – 9:30 AM Concurrent Session I: Diagnostics
Moderators: C. Richard Boland, MD; Elena M. Stoffel, MD, MPH
Ascertainment of Lynch Syndrome – The Geisinger Experience
Alanna L. Kulchak Rahm, PhD, MS, LCGC
PDF Slides: Ascertainment of Lynch Syndrome – The Geisinger Experience
Recorded Presentation: Ascertainment of Lynch Syndrome The Geisinger Experience
Preimplantation Genetic Diagnosis
Shane Lipskind, MD, FACOG
PDF Slides: Hereditary Colorectal Cancer Syndromes-Reproductive Options and Fertility
Recorded Presentation: Preimplantation Genetic Diagnosis
Upfront Tumor Sequencing for CRC
Heather Hampel, MS, LGC
PDF Slides: Upfront Tumor Sequencing to replace all other molecular tests for colorectal cancer
Recorded Presentation: Upfront Tumor Sequencing for CRC
9:45 – 10:15 AM Randall W. Burt Lectureship
Introductions by Wendy K. Kohlmann, MS, CGC
PDF Slides: Randall W. Burt, MD Lectureship Introductions
Adenomatous Polyposis Syndromes Genetics and Phenotype
Randall W. Burt, MD
PDF Slides: Adenomatous Polyposis Syndromes?Genetics and Phenotype
Recorded Presentation: Adenomatous Polyposis Syndromes Genetic and Phenotype
10:15 – 11:40 AM Presidential Plenary Abstract Session II
Moderators: Michael J. Hall, MD, MS; Heather Hampel, MS, LGC
Detecting Unaffected Individuals for Lynch Syndrome (DUAL): An Institutional Experience
Sayoni Lahiri, MS, CGC
PDF Slides: Detecting Unaffected Individuals for Lynch Syndrome (DUAL) An Institutional Experience
Recorded Presentation: Detecting Unaffected Individuals for Lynch Syndrome (DUAL): An Institutional Experience
Lynch Syndrome and Breast Cancer: Association or Incidental Finding?
Jessica Stoll, MS, CGC
PDF Slides: Lynch Syndrome and Breast Cancer- Association or Incidental Finding
Recorded Presentation: Lynch Syndrome and Breast Cancer- Association or Incidental Finding
Clinical Presentation of Constitutional Mismatch Repair Deficiency
Maegan E. Roberts, MS, LCGC
PDF Slides: Clinical Presentation of Constitutional Mismatch Repair Deficiency
Recorded Presentation: Clinical Presentation of Constitutional Mismatch Repair Deficiency
Explaining an Atypical Immunohistochemical Pattern Using Paired Tumor/Germline Testing for Lynch Syndrome
Kelly Fulk, MS, CGC
PDF Slides: Explaining an Atypical Immunohistochemical Pattern Using Paired Tumor:Germline Testing for Lynch
Recorded Presentation: Explaining an Atypical Immunohistochemical Pattern Using Paired Tumor
An International Interlaboratory Study of Complex Pathogenic Variants In Inherited Colorectal Cancer
Stephen Lincoln
Recorded Presentation: An International Interlaboratory Study Of Complex Pathogenic Variants In Inherited Colorectal Cancer
Prevalence and molecular correlates of mono- and bi-allelic pathogenic somatic mutations in the mismatch repair (MMR) genes among 24,233 histologically diverse tumors undergoing tumor genomic profiling
Michael J. Hall, MD, MS
Recorded Presentation: Prevalence and molecular correlates of mono- and bi-allelic pathogen
Clinical factors associated with urinary tract cancers among individuals with Lynch syndrome
Matthew B. Yurgelun, MD
Recorded Presentation: Clinical factors associated with urinary tract cancers among individuals with Lynch syndrome
Clinical Factors Associated with Gastric Cancers among Lynch Syndrome Patients
Presented by Matthew B. Yurgelun, MD on behalf of Jaihwan Kim, MD
Recorded Presentation: Clinical Factors associated with gastric cancers among Lynch Syndrome patients
Time from Genetic Test Result to First Colonoscopy in Lynch Patients with Personal/Family History of Breast and/or Gynecologic Cancers
Karen E. Hurley, PhD
Recorded Presentation: Time from Genetic Test Result to First Colonoscopy in Lynch Patients
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11:40 – 11:55 AM
Collaborative Fund Recipient Update
Presented by Cecilia Bellcross, PhD, MS, CGC; Amie Blanco, MS, LGC
PDF Slides: Collaborative Fund Update
Recorded Presentation: Collaborative Fund Recipient Update